Vice launched his stand-up career in Punchline and The Library, whose manager Andrew de Real gave him the screen name “Vice Ganda”. There he spent several years developing his materials in the comedy clubs. Vice’s career began to build after appearances on television and reviews from tabloid columns. He work alongside fellow comedians Chocoleit, Pooh, John Lapus and Rey Kilay.
He appeared in several TV series and sitcoms but his character in Dyosa under the direction of Wenn V. Deramas gave him prominence with local TV viewers. Vice also had another supporting role in the drama series Maging Sino Ka Man: Ang Pagbabalik. In 2009, he became part of Showtime, a talent search program which made him a regular host/judge until present. His life story of being bullied as a young closeted gay has also been featured in the drama anthology, Maalaala Mo Kaya. Aside from Showtime, he is currently hosting his own Sunday talk show, the consistently top rated Gandang Gabi, Vice!. Currently he is under the management of ABS-CBN, handling him is business unit head Deo Endrinal after being managed for four years by local entertainment columnist/host Ogie Diaz.
Vice starred in minor roles until in 2009 where he appeared alongside Vilma Santos and John Lloyd Cruz in the film In My Life, depicting a story of a young Filipino gay couple struggling life in New York when one of their parents tries to live with them. A year later he starred in a comedy film, a remake of Petrang Kabayo. It proved to be a hit when it was released. The following year, Vice starred in Praybeyt Benjamin with Derek Ramsay directed by Wenn V. Deramas. The movie became the first local film to reach 300-million Pesos in ticket sales and proved to be an even greater box office success than Petrang Kabayo. He is presently under contract with Viva Films.
On June 15, 2011, Vice released his first studio album, Vice Ganda: Lakas Tama. The album was released under Vicor Records and featured mostly pop and novelty songs including "Palong Palo" written by Callalily frontman Kean Cipriano. He is also included in the compilation album of Showtime released by Star Records.